Development of Floating-Mucoadhesive Microsphere for Site Specific Release of Metronidazole
نویسندگان
چکیده
منابع مشابه
Development of Floating-Mucoadhesive Microsphere for Site Specific Release of Metronidazole.
PURPOSE The purpose of this study was to develop and evaluate metronidazole loaded floating-mucoadhesive microsphere for sustained drug release at the gastric mucosa. METHODS Alginate gastroretentive microspheres containing metronidazole were prepared by ionic gelation method using sodium bicarbonate as gas forming agent, guar gum as mucoadhesive polymer, and Eudragit L100 as drug release mod...
متن کاملDevelopment and evaluation of regioselective bilayer floating tablets of Atenolol and Lovastatin for biphasic release profile
This study was performed to design bilayer regioselective floating tablets of atenolol and lovastatin to give immediate release of lovastatin and sustained release of atenolol. Bilayer floating tablets comprised two layers, i.e immediate release and controlled release layers. The immediate release layer comprised sodium starch glycollate as a super disintegrant and the sustained release layer c...
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The retention of drug delivery systems in the stomach for longer time is required to improve the bioavailability and therapeutic efficacy of the drugs used for the diseases associated with the stomach. In the present work, gastro-retentive floating beads of sodium alginate (SA) were prepared through ionotropic gelation with divalent Ca ions and covalent cross-linking with glutaraldehyde (GA). M...
متن کاملDevelopment and evaluation of regioselective bilayer floating tablets of Atenolol and Lovastatin for biphasic release profile
This study was performed to design bilayer regioselective floating tablets of atenolol and lovastatin to give immediate release of lovastatin and sustained release of atenolol. Bilayer floating tablets comprised two layers, i.e immediate release and controlled release layers. The immediate release layer comprised sodium starch glycollate as a super disintegrant and the sustained release layer c...
متن کاملMucoadhesive Microsphere: A Review
The conventional oral dosage forms have regarding the short duration of delivery to system. A controlled release system designed to increase its residence time in stomach with contact with mucosa was achieved by the formulation of mucoadhesive microsphere of the drug. The aim of the present study is to provide an overview of various aspects of mucoadhesive microsp various polymers, preparation ...
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ژورنال
عنوان ژورنال: Advanced Pharmaceutical Bulletin
سال: 2016
ISSN: 2228-5881,2251-7308
DOI: 10.15171/apb.2016.027